The Leader made remarks while addressing Muslim ambassadors, Iranian officials and ordinary people in Tehran Monday during a meeting on the occasion of Eid al-Fitr.
The leader also stressed that Muslims today are obliged to fight Israel with whatever means they possess.
“According to Islamic jurisprudence, when an enemy takes over Muslim lands, Jihad in any possible form becomes everyone's duty," Ayatollah Khamenei said, adding, “Today the fight against the Zionist regime is obligatory and necessary for Muslims. Why do some evade this duty?”
The Leader warned of the "great danger of consigning the Palestinian issue to oblivion."
“Palestine is the number one issue of the Islamic world, but some Islamic countries are acting in such a way as to have the Palestinian case ignored and forgotten."
The leader also touched on the ongoing conflicts in Yemen, Syria, Iraq and North Africa,
The Leader further hailed Quds Day rallies on Friday and the massive public turnout in Tehran and other cities across Iran to defend the Palestinian people as "a proud example of Islamic unity."
"The meaning of the Islamic unity is that the Shia and fasting people come to the streets with such magnificence and express empathy and sympathy with Palestinians who are Sunni."
Ayatollah Khamenei described disunity as "the most important problem and a great wound on the body of the Islamic world" in the face of the enemies' efforts to fan the flames of sectarian, religious and territorial strife.
"Division and discord are harmful to Islam and the Islamic Ummah. On the other hand, proximity among Islamic countries and avoiding the use of force against one another is in accordance with divine wisdom and in the interest of all Islamic countries."